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Plasma hydroxy-metronidazole/metronidazole Ratio Can Detect Early Changes in Hepatic Function in Ethanol-Induced Liver Injury

Plasma hydroxy-metronidazole/metronidazole Ratio Can Detect Early Changes in Hepatic Function in Ethanol-Induced Liver Injury

C M Da Silva, F L David, M N Muscará, S S Sousa, J G Ferraz, G De Nucci, N C Polimeno, J Pedrazzoli

Aliment Pharmacol Ther. 1999 Oct;13(10):1335-41.

PMID: 10540049

Abstract:

Aims:
To evaluate the usefulness of plasma hydroxy-metronidazole/metronidazole (OH-MET/MET) ratios as a dynamic liver function test in ethanol abusers with or without liver cirrhosis.
Methods:
Metronidazole was administered intravenously for 20 min to healthy volunteers, and to patients with alcohol-induced, non-cirrhotic hepatopathy and liver cirrhosis. Plasma concentrations of metronidazole and hydroxy-metronidazole were measured by high performance liquid chromatography in samples collected 5, 10, 20 and 30 min after the metronidazole infusion.
Results:
Patients with non-cirrhotic alcoholic hepatopathy had significantly elevated aminotransferase levels compared to healthy volunteers and Child A patients. Child-Pugh C patients had significantly prolonged prothrombin times when compared to healthy volunteers and patients with non-cirrhotic hepatopathy. Metronidazole metabolism, as measured by the OH-MET/MET ratio following the intravenous administration of 500 mg of the drug, was significantly impaired in all ethanol-abusing individuals, including patients with non-cirrhotic alcoholic hepatopathy.
Conclusions:
Metronidazole metabolism was impaired in ethanol abusers, even in the absence of liver cirrhosis, indicating that ethanol was capable of affecting liver function in the early stages of alcohol-induced liver disease.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP4812402	Metronidazole-OH		4812-40-2	Price

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