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Plasma, Tissue and Urinary Levels of Aloin in Rats After the Administration of Pure Aloin

Plasma, Tissue and Urinary Levels of Aloin in Rats After the Administration of Pure Aloin

Mi-Young Park, Hoon-Jeong Kwon, Mi-Kyung Sung

Nutr Res Pract. Spring 2008;2(1):17-21.

PMID: 20126360

Abstract:

Aloin is a physiologically active anthraquinone present in aloe. There are two isomers of aloin, aloin A and aloin B, occurring as a mixture of diastereomers. The objective of this study was to determine the bioavailability and tissue distribution of aloin. Rats were gavaged with 11.8g/kg aloin, and the levels of aloin and its conjugates were measured in plasma, tissues, and urine. Plasma aloin level showed a peak at 1hr after the administration and the concentration was 59.07+/-10.5 ng/ml. The 24 h cumulated urinary aloin was 0.03% of the initial dose. These results suggest that aloin is absorbed and reaches a peak plasma level within 1-1.5 h after the administration and a significant portion is possibly metabolized or is excreted in feces. These results can apply to the determination of the adequate intake level of aloe and aloe products to achieve the desired biological effect, and to interprete in vitro study results.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP28371166	Aloin B		28371-16-6	Price

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