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Platelet-activating Factor Acetylhydrolase (PAF-AH) in Human Kidney

Platelet-activating Factor Acetylhydrolase (PAF-AH) in Human Kidney

S Antonopoulou, C A Demopoulos, C Iatrou, G Moustakas, P Zirogiannis

Int J Biochem. 1994 Sep;26(9):1157-62.

PMID: 7988740

Abstract:

1. PAF-AH activity in human kidney (cortex and medulla) has been demonstrated and shares the following properties. 2. Does not require the presence of Ca2+ and appears to be different from phospholipase A2. 3. The pH optimum shows a peak at 7-7.4. 4. It is stable for 4 days at -30 degrees C. 5. It is mainly distributed in the microsomal fraction. 6. The apparent Km values of the enzymes of cortex and medulla are 0.553 and 0.207 microM, respectively and distinct from serum PAF-AH (1.439 microM). 7. The apparent molecular weight values are 60,000 and 25,000 for medulla and cortex, respectively and distinct from serum PAF-AH (94,000).

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
IAR4247432	PAF-AH human			Price

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