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Platelet Activation by Endogenous 5-hydroxytryptamine and Histamine Released by Mast Cell Degranulation With Compound 48/80 in the Rat

Platelet Activation by Endogenous 5-hydroxytryptamine and Histamine Released by Mast Cell Degranulation With Compound 48/80 in the Rat

F De Clerck, Y Somers, L Van Gorp, B Xhonneux

Agents Actions. 1983 Feb;13(1):81-7.

PMID: 6858790

Abstract:

The intravenous injection of the mast cell degranulator C 48/80 (1 mg/kg) in rats did not produce thrombocytopenia nor circulating platelet aggregates but sensitized the platelets to aggregate upon turbulence challenge. Such turbulence-induced platelet aggregation was not accompanied by formation of thromboxane B2. Electron microscopy revealed absence of platelet degranulation. Turbulence-induced platelet aggregation was completely prevented by pre-treatment of the rats with cyproheptadine, dipyridamole and VK 774, partially with ketanserin (5HT2-receptor antagonist), but not with methysergide (antiserotonergic drug), pyrilamine (antihistaminic drug), suprofen, aspirin (cyclo-oxygenase inhibitors), phentolamine, propranolol, flunarizine, lidoflazine, oxycoumarin or Trasylol. Combined treatment with the anti-histaminic drug pyrilamine and the 5HT2-receptor antagonist ketanserin resulted in a dose-related inhibition for ketanserin of the turbulence-induced platelet aggregation. These experiments point to an interaction between histamine and 5-hydroxytryptamine in the platelet activation by mast cell released mediators.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP3967326	Cyproheptadine Related Compound C		3967-32-6	Price

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