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Poly(ethylene Glycol) dicarboxylate/poly(ethylene Oxide) Hydrogel Film Co-Crosslinked by Electron Beam Irradiation as an Anti-Adhesion Barrier

Poly(ethylene Glycol) dicarboxylate/poly(ethylene Oxide) Hydrogel Film Co-Crosslinked by Electron Beam Irradiation as an Anti-Adhesion Barrier

Haryanto, Deepti Singh, Sung Soo Han, Jun Hyuk Son, Seong Cheol Kim

Mater Sci Eng C Mater Biol Appl. 2015 Jan;46:195-201.

PMID: 25491977

Abstract:

The cross-linked poly(ethylene glycol) dicarboxylate (PEGDC)/poly(ethylene oxide) (PEO) and poly(ethylene glycol) dimethacrylate (PEGDMA)/(PEO) hydrogels were developed for possible biomedical applications such as an anti-adhesion barrier. Various contents of PEGDC/PEO film were irradiated using an electron beam with various beam intensities in order to obtain various degrees of crosslinked hydrogels. The optimum dose (300 kGy) and total crosslinker content of 10% were used to prepare crosslinked hydrogel films with three different compositions (10% PEGDC, 10% PEGDMA, 5% PEGDC-5% PEGDMA). Among them, 10% PEGDC hydrogel film exhibited the highest elongation at break (69.33±6.87%) with high mechanical strength. 10% PEGDC hydrogel film showed the lowest hemolysis activity (6.03±0.01%) and the highest tissue adherence (75.67±1.15 cN). The result also indicated that the carboxyl groups in PEGDC affect the tissue adherence of hydrogel films via H-bonding interactions. In animal studies, 10% PEGDC anti-adhesion hydrogel film degraded within 3 weeks and demonstrated better anti-adhesive effect compared to Guardix-SG®.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP25852475	Poly(ethylene glycol) dimethacrylate		25852-47-5	Price

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