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Poly(lactide-co-glycolide) Microparticles as Systems for Controlled Release of Proteins -- Preparation and Characterization

Poly(lactide-co-glycolide) Microparticles as Systems for Controlled Release of Proteins -- Preparation and Characterization

Aleksandra Porjazoska, Katerina Goracinova, Kristina Mladenovska, Marija Glavas, Maja Simonovska, Emilija Ivanovska Janjević, Maja Cvetkovska

Acta Pharm. 2004 Sep;54(3):215-29.

PMID: 15610618

Abstract:

Poly(DL-lactide-co-glycolide) (PDLLGA) and poly(L-lactide-co-glycolide) (PLLGA) copolymers were prepared by bulk ring opening polymerization of lactide and glycolide and characterized by GPC, FTIR, 1H NMR and DSC. Copolymers with different molar masses at a constant lactide/glycolide ratio were used for preparation of bovine serum albumin (BSA)-loaded microparticles by the double emulsion w/o/w method. The influence of the copolymer molar mass and composition on the microparticle morphology, size, yield, degradation rate, BSA-loading efficiency and BSA release profile were studied. For microparticles prepared from PDLLGA copolymers, a biphasic profile for BSA release was found and for those made from PLLGA copolymers the release profile was typically triphasic; both of them were characterized by high initial burst release. Possible reasons for such behavior are discussed.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
LS74383	Poly(L-lactide-co-glycolide)			Price

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