Home
Resources
Publications
Poly(methyl Vinyl Ether-Alt-Maleic Acid) Polymers for Cell Encapsulation

Poly(methyl Vinyl Ether-Alt-Maleic Acid) Polymers for Cell Encapsulation

Casandra M Gardner, Nicholas A D Burke, Terry Chu, Feng Shen, Murray A Potter, Harald D H Stöver

J Biomater Sci Polym Ed. 2011;22(16):2127-45.

PMID: 21067656

Abstract:

Polyanions based on poly(methyl vinyl ether-alt-maleic acid) were investigated as materials for cell encapsulation. These water-soluble polyanions having molecular masses ranging from 20 to 1980 kDa were prepared by functionalization of poly(methyl vinyl ether-alt-maleic anhydride) with 5-aminofluorescein and/or α-methoxy-ω-amino-poly(ethylene glycol), followed by base hydrolysis of the residual anhydride groups to form the corresponding poly(methyl vinyl ether-alt-sodium maleate). Their potential to replace alginate both in the core and, in particular, the outer shell of calcium alginate-poly(L-lysine)-alginate (APA) capsules was determined using confocal fluorescence microscopy, osmotic pressure tests, permeability studies, protein binding and cell viability assays. These polymers were shown to be able to replace the outer layer of alginate, forming more resilient capsule shells. The resulting capsules showed similar permeability and resistance to bovine serum albumin binding, as well as superior viability for encapsulated cells, when compared to standard APA capsules. In addition, these polymers showed promise for use as functional additives to the capsule cores.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP25153406	Poly(methyl vinyl ether-alt-maleic acid)		25153-40-6	Price

As a specialist in analytical chemical Products, Alfa Chemistry offers consumers a wealth of raw materials and a full range of technologies and services.

QUICK LINKS

HEADQUARTERS

Tel:

Fax:

Email: