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Poly(N-isopropylacrylamide) and Copolymers: A Review on Recent Progresses in Biomedical Applications

Poly(N-isopropylacrylamide) and Copolymers: A Review on Recent Progresses in Biomedical Applications

Sonia Lanzalaco, Elaine Armelin

Gels. 2017 Oct 4;3(4):36.

PMID: 30920531

Abstract:

The innate ability of poly(N-isopropylacrylamide) (PNIPAAm) thermo-responsive hydrogel to copolymerize and to graft synthetic polymers and biomolecules, in conjunction with the highly controlled methods of radical polymerization which are now available, have expedited the widespread number of papers published in the last decade-especially in the biomedical field. Therefore, PNIPAAm-based hydrogels are extensively investigated for applications on the controlled delivery of active molecules, in self-healing materials, tissue engineering, regenerative medicine, or in the smart encapsulation of cells. The most promising polymers for biodegradability enhancement of PNIPAAm hydrogels are probably poly(ethylene glycol) (PEG) and/or poly(ε-caprolactone) (PCL), whereas the biocompatibility is mostly achieved with biopolymers. Ultimately, advances in three-dimensional bioprinting technology would contribute to the design of new devices and medical tools with thermal stimuli response needs, fabricated with PNIPAAm hydrogels.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
LS74686	Poly(N-isopropylacrylamide)			Price

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