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Polyethylene Glycol-Conjugated Chondroitin Sulfate A Derivative Nanoparticles for Tumor-Targeted Delivery of Anticancer Drugs

Polyethylene Glycol-Conjugated Chondroitin Sulfate A Derivative Nanoparticles for Tumor-Targeted Delivery of Anticancer Drugs

Jae-Young Lee, Ju-Hwan Park, Jeong-Jun Lee, Song Yi Lee, Suk-Jae Chung, Hyun-Jong Cho, Dae-Duk Kim

Carbohydr Polym. 2016 Oct 20;151:68-77.

PMID: 27474544

Abstract:

Polyethylene glycol (PEG)-decorated chondroitin sulfate A-deoxycholic acid (CSD) nanoparticles (NPs) were fabricated for the selective delivery of doxorubicin (DOX) to ovarian cancer. CSD-PEG was synthesized via amide bond formation between the NH2 group of methoxypolyethylene glycol amine and the COOH group of CSD. CSD-PEG/DOX NPs with a 247nm mean diameter, negative zeta potential, and >90% drug encapsulation efficiency were prepared. Sustained and pH-dependent DOX release profiles from CSD-PEG NPs were observed in dissolution tests. Endocytosis of NPs by SKOV-3 cells (CD44 receptor-positive human ovarian cancer cells), based on the CSA-CD44 receptor interaction, was determined by flow cytometry and confocal laser scanning microscopy (CLSM) studies. PEGylation of NPs also resulted in reduced drug clearance (CL) in vivo and improved relative bioavailability, compared to non-PEGylated NPs, as determined by the pharmacokinetic study performed after intravenous administration in rats. Developed CSD-PEG NPs can be a promising delivery vehicle for the therapy of CD44 receptor-expressing ovarian cancers.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP80506645	Methoxypolyethylene glycol amine		80506-64-5	Price

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