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Polymorphic Phase Transitions in Carbamazepine and 10,11-Dihydrocarbamazepine

Polymorphic Phase Transitions in Carbamazepine and 10,11-Dihydrocarbamazepine

Alexander E Clout, Asma B M Buanz, Simon Gaisford, Gareth R Williams

Chemistry. 2018 Sep 12;24(51):13573-13581.

PMID: 29979477

Abstract:

Temperature-induced phase transitions in carbamazepine (CBZ) and 10,11-dihydrocarbamazepine (DHC) were studied by simultaneous differential scanning calorimetry-X-ray diffraction in this work. The transitions generally involve a transitional melt phase which is quickly followed by recrystallisation. The expansions of the unit cell as a function of temperature could be quantified and allow us to determine a directional order of stability in relation to the lattice constants. Dihydrocarbamazepine form II undergoes a conversion to form I by a localised melt phase. Carbamazepine (CBZ) form IV converts to form I at 182 °C, again by a localised intermediate melt phase. CBZ form II converted to form I at 119 °C by a pathway that appears to have included some melting, and form III underwent a part melt-recrystallisation and a part sublimation-recrystallisation to form I.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP3564736-A	10,11-Dihydrocarbamazepine		3564-73-6	Price

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