Home
Resources
Publications
Potential Anthelmintics: Polyphenols From the Tea Plant Camellia Sinensis L. Are Lethally Toxic to Caenorhabditis Elegans

Potential Anthelmintics: Polyphenols From the Tea Plant Camellia Sinensis L. Are Lethally Toxic to Caenorhabditis Elegans

Daisuke Mukai, Noriko Matsuda, Yu Yoshioka, Masashi Sato, Toru Yamasaki

J Nat Med. 2008 Apr;62(2):155-9.

PMID: 18404315

Abstract:

A novel gallate of tannin, (-)-epigallocatechin-(2 beta-->O-->7',4 beta-->8')-epicatechin-3'-O-gallate (8), together with (-)-epicatechin-3-O-gallate (4), (-)-epigallocatechin (5), (-)-epigallocatechin-3-O-gallate (6), and (+)-gallocatechin-(4 alpha-->8')-epigallocatechin (7), were isolated from the tea plant Camellia sinensis (L.) O. Kuntze var. sinensis (cv., Yabukita). The structure of 8, including stereochemistry, was elucidated by spectroscopic methods and hydrolysis. The compounds, along with commercially available pyrogallol (1), (+)-catechin (2), and (-)-epicatechin (3), were examined for toxicity towards egg-bearing adults of Caenorhabditis elegans. The anthelmintic mebendazole (9) was used as a positive control. Neither 2 nor 3 were toxic but the other compounds were toxic in the descending order 8, 7 approximately 6, 9, 4, 5, 1. The LC(50) (96 h) values of 8 and 9 were evaluated as 49 and 334 micromol L(-1), respectively. These data show that many green tea polyphenols may be potential anthelmintics.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
IAR42410449	(±)-Epigallocatechin-2,3,4-13C3			Price
IAR42410453	(±)-Epigallocatechin-2,3,4-13C3 gallate			Price

As a specialist in analytical chemical Products, Alfa Chemistry offers consumers a wealth of raw materials and a full range of technologies and services.

QUICK LINKS

HEADQUARTERS

Tel:

Fax:

Email: