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Potential Physiological Importance of Pyrroloquinoline Quinone

Potential Physiological Importance of Pyrroloquinoline Quinone

Robert Rucker, Winyoo Chowanadisai, Masahiko Nakano

Altern Med Rev. 2009 Sep;14(3):268-77.

PMID: 19803551

Abstract:

Pyrroloquinoline quinone (PQQ) is a novel biofactor for which a proposition can be made for physiological importance. PQQ was first recognized as an enzyme cofactor in bacteria. It has recently been tentatively identified as a component of interstellar dust. Thus, PQQ may have been present throughout early biological conception and evolution. PQQ is also a potent plant growth factor. Consequently, for animals and humans, there has been constant exposure to PQQ. In animals, PQQ is reported to participate in a range of biological functions with apparent survival benefits (e.g., improved neonatal growth and reproductive performance). There are also benefits from PQQ supplementation related to cognitive, immune, and antioxidant functions, as well as protection from cardiac and neurological ischemic events. Although PQQ is not currently viewed as a vitamin, its involvement in cell signaling pathways, particularly those important to mitochondriogenesis in experimental animal models, may eventually provide a rationale for defining PQQ as vital to life. For humans, such evidence suggests there may be similar parallels or benefits from improving PQQ status.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP72909343	Pyrroloquinoline quinone		72909-34-3	Price

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