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Potentiation of the Negative Chronotropic and Inotropic Effects of Adenosine by 2-phenylaminoadenosine

S Chiba, H Watanabe

Clin Exp Pharmacol Physiol. Jan-Feb 1983;10(1):1-5.

PMID: 6839549

Abstract:

1. Effects of 2-phenylaminoadenosine on SA nodal pacemaker activity and atrial contractility were studied, using eleven isolated, blood-perfused dog atrial preparations. The compounds were administered via the cannulated sinus node artery of the isolated atrium. 2. 2-Phenylaminoadenosine induced negative chronotropic and inotropic effects and was 100 times less potent than adenosine in this action. 3. The interaction between adenosine and 2-phenylaminoadenosine was studied. 2-Phenylaminoadenosine potentiated the effect of adenosine on atrial muscle, but not that of acetylcholine.

Chemicals Related in the Paper:

Catalog Number Product Name Structure CAS Number Price
IAR4244617 2-Phenylaminoadenosine 2-Phenylaminoadenosine Price
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