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Practical Preparation of Ethyl 2-methylthiophene-3-carboxylate

Masakazu Kogami, Nobuhide Watanabe

Chem Pharm Bull (Tokyo). 2011;59(6):797-8.

PMID: 21628923

Abstract:

A safe and efficient process for the preparation of ethyl 2-methylthiophene-3-carboxylate (5) was devised. This process provides several advantages over the precedents, involving operational simplicity, avoidance of the use of strong bases such as n-butyllithium and application of noncryogenic conditions, and enabled to prepare 5 in 52% overall yield from commercially available 2-methylthiophene on a multikilogram scale.

Chemicals Related in the Paper:

Catalog Number Product Name Structure CAS Number Price
AP554143 2-Methylthiophene 2-Methylthiophene 554-14-3 Price
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