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Pre-filled Syringes: A Review of the History, Manufacturing and Challenges

Gregory Sacha, J Aaron Rogers, Reagan L Miller

Pharm Dev Technol. 2015 Jan;20(1):1-11.

PMID: 25589433

Abstract:

Pre-filled syringes are convenient devices for the delivery of parenteral medications. They are small which makes them easy to carry and are dependable for delivering a precise dose of medication. These and many other reasons are leading to their growth in the pharmaceutical market. There are a number of review articles that describe the advantages and disadvantages of pre-filled syringes. However, there are few journal articles that present information on their manufacturing and challenges. The intent of this review article is to provide information on the history of the pre-filled syringe, methods of their manufacture, methods of filling syringes as a drug product and to examine the types of syringes available. This type of knowledge can familiarize the formulation scientist with the choices available and their possible challenges.

Chemicals Related in the Paper:

Catalog Number Product Name Structure CAS Number Price
CS31041225 Cyclic olefin polymer Cyclic olefin polymer Price
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