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Prediction of Bioavailability of Selected Bisphosphonates Using in Silico Methods Towards Categorization Into a Biopharmaceutical Classification System

Prediction of Bioavailability of Selected Bisphosphonates Using in Silico Methods Towards Categorization Into a Biopharmaceutical Classification System

Joanna Biernacka, Katarzyna Betlejewska-Kielak, Ewa Kłosińska-Szmurło, Franciszek A Pluciński, Aleksander P Mazurek

Acta Pol Pharm. Sep-Oct 2013;70(5):877-82.

PMID: 24147367

Abstract:

The physicochemical properties relevant to biological activity of selected bisphosphonates such as clodronate disodium salt, etidronate disodium salt, pamidronate disodium salt, alendronate sodium salt, ibandronate sodium salt, risedronate sodium salt and zoledronate disodium salt were determined using in silico methods. The main aim of our research was to investigate and propose molecular determinants thataffect bioavailability of above mentioned compounds. These determinants are: stabilization energy (deltaE), free energy of solvation (deltaG(solv)), electrostatic potential, dipole moment, as well as partition and distribution coefficients estimated by the log P and log D values. Presented values indicate that selected bisphosphonates a recharacterized by high solubility and low permeability. The calculated parameters describing both solubility and permeability through biological membranes seem to be a good bioavailability indicators of bisphosphonates examined and can be a useful tool to include into Biopharmaceutical Classification System (BCS) development.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP138844812	Ibandronate sodium salt		138844-81-2	Price

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