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Preincubation of Thymocytes With 1-(5-isoquinolinesulfonyl)-2-methylpiperazine Dihydrochloride (H-7) Induces Apoptosis in Non-Stimulated Thymocytes

Preincubation of Thymocytes With 1-(5-isoquinolinesulfonyl)-2-methylpiperazine Dihydrochloride (H-7) Induces Apoptosis in Non-Stimulated Thymocytes

Y Sakurai, C Hirata, Y Onishi, Y Tanimoto, T Yamada, H Kizaki

Biochem Mol Biol Int. 1997 Jul;42(3):433-41.

PMID: 9247701

Abstract:

1-(5-Isoquinolinesulfonyl1)-2-methylpiperazine hydrochloride (H-7), an inhibitor of protein kinases, has been shown to inhibit the thymocyte apoptosis induced by various apoptogenic agents. In the present study, when mouse thymocytes were pretreated with H-7, washed, and cultured for an additional time, apoptosis was induced depending on the preincubation time and the dose of H-7. The protein kinase C activity in the H-7-pretreated and -washed cells was not altered, suggesting that an alteration of a certain PKC isoform is related to both the triggering and the progression of apoptosis.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP108930172-A	H-7 dihydrochloride		108930-17-2	Price

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