Home
Resources
Publications
Preliminary Applicability Tests of Different Methacrylic Acid Copolymers, Type C NF, Particularly Relevant to Spreading and Film Formation

Preliminary Applicability Tests of Different Methacrylic Acid Copolymers, Type C NF, Particularly Relevant to Spreading and Film Formation

V Binder, S Hirsch, S Scheiffele, K H Bauer

Eur J Pharm Biopharm. 1998 Sep;46(2):229-32.

PMID: 9867439

Abstract:

The intention of this study was to show under which conditions a film forming methacrylic acid copolymer coating excipient, corresponding to the requirements of pharmacopoeia, but obtained from different sources, can be substituted without severe problems. The mechanical properties of the film coats were investigated by dynamic-mechanical thermo-analysis (DMTA) experiments to determine with respect to the glass transition the storage modulus E', the loss modulus E'', and the loss factor tan delta. Further determinations concerned the surface tensions of the different coating dispersions. This attribute plays an important role in spreading, distribution and coalescence of the film forming preparations. Finally by a series of small experimental fluidized bed batches cores containing a model drug were coated with the different methacrylic acid copolymers. The resistance of these coated tablets in 0.1 N HC1 as well as their dissolution rates in artificial intestinal juice were tested. The coatings proved themselves so similar that in this case substitutions of products of different provenance are possible. The determinations of surface tension and the DMTA measurements seem to be useful and reliable preliminary applicability tests.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP25086151-C	Methacrylic acid copolymer type C		25086-15-1	Price

As a specialist in analytical chemical Products, Alfa Chemistry offers consumers a wealth of raw materials and a full range of technologies and services.

QUICK LINKS

HEADQUARTERS

Tel:

Fax:

Email: