Home
Resources
Publications
Prenatal Stress Alters Noradrenergic Modulation of LTP in Hippocampal Slices

Prenatal Stress Alters Noradrenergic Modulation of LTP in Hippocampal Slices

Gayane Grigoryan, Menahem Segal

J Neurophysiol. 2013 Jul;110(2):279-85.

PMID: 23615548

Abstract:

Long-term effects of stress during pregnancy on brain and behavior have been analyzed extensively in recent years. These effects include changes in emotional behavior, a reduction in learning capacity, and ability to generate long-term potentiation (LTP) in the offspring. In earlier studies, we and others have described a difference in ability to express LTP in dorsal and ventral sectors of the hippocampus (DH and VH, respectively) and its modification by prior stress. We now found that norepinephrine (NE) facilitated conversion of short-term potentiation to LTP in the normal DH but not in VH. Prenatal stress (PS) switched the locus of the facilitating action of NE from the DH to the VH. The effects of NE are likely to be mediated by activation of calcium stores. PS also facilitated (S)-3,5-dihydroxyphenylglycine hydrate (DHPG)-induced LTD in the VH, assumed to be mediated by release of calcium from stores. These observations have important implications for the role of the hippocampus in cognitive and emotional memories.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
ALP162870293	(S)-3,5-Dihydroxyphenylglycine hydrate		162870-29-3 (anhydrous)	Price

As a specialist in analytical chemical Products, Alfa Chemistry offers consumers a wealth of raw materials and a full range of technologies and services.

QUICK LINKS

HEADQUARTERS

Tel:

Fax:

Email: