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Prenylflavonoids and Phloroglucinol Derivatives From Hops (Humulus Lupulus)

Feng Zhao, Yuki Watanabe, Hajime Nozawa, Akihiro Daikonnya, Keiji Kondo, Susumu Kitanaka

J Nat Prod. 2005 Jan;68(1):43-9.

PMID: 15679315

Abstract:

The ethyl acetate soluble fraction of hops (Humulus lupulus) showed potent inhibitory activity on the production of nitric oxide (NO) induced by a combination of LPS and IFN-gamma. Four known prenylflavonoids (1-4) and a new prenylflavonoid (5), hulupinic acid (6), lupulone (7), and its six new derivatives (8-13) were isolated from the active fraction. The structures were determined on the basis of physiochemical properties and spectroscopic analysis. Their inhibitory activities on the production of NO in macrophage RAW 264.7 cells were examined.

Chemicals Related in the Paper:

Catalog Number Product Name Structure CAS Number Price
AP1891425 Hulupinic acid Hulupinic acid 1891-42-5 Price
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