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Preparation and Characterization of Aminoethyl Hydroxypropyl Methyl Cellulose Modified With Nisin

Preparation and Characterization of Aminoethyl Hydroxypropyl Methyl Cellulose Modified With Nisin

Lihong Fan, Jin Hu, Zhihai Hu, Min Peng, Huigao Wen, Ya Li, Tan Wang

Int J Biol Macromol. 2016 Aug;89:62-9.

PMID: 26968923

Abstract:

Nisin grafted aminoethyl hydroxypropyl methyl cellulose (AEHPMC) was prepared by an enzyme-catalyzed reaction in the presence of microbial transglutaminase (MTGase). AEHPMC was synthesized with 2-chloroethylamine hydrochloride (CEH) which was as an intermediate reactant. The parameters, which influenced the NH2% and the degree of substitution (DS), including reaction time, reaction temperature and the mass ratio of the reactants were investigated. Antioxidant activities of AEHPMC-nisin were evaluated by the scavenging activity of hydroxyl and 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical. With the DS and concentration increasing of AEHPMC-nisin, the radical scavenging activity increased. The Methylthiazol tetrazolium (MTT) assay indicated that AEHPMC-nisin had low-toxicity to L929 cells. Therefore, the derivative of HPMC may show a promising potential application in biomedical, food and pharmaceutical fields.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP9004653	(Hydroxypropyl)methyl cellulose		9004-65-3	Price

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