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Preparation and Characterization of Size-Controlled Nanoparticles for High-Loading λ-Cyhalothrin Delivery Through Flash Nanoprecipitation

Kai Chen, Zhinan Fu, Mingwei Wang, Yin Lv, Chunxin Wang, Yue Shen, Yan Wang, Haixin Cui, Xuhong Guo

J Agric Food Chem. 2018 Aug 8;66(31):8246-8252.

PMID: 30016093

Abstract:

Environmental concerns and low efficacy pose a challenge for the application of traditional insecticide formulations. In this study, a series of λ-cyhalothrin (LC)-loaded nanoparticles (NPs) were produced by flash nanoprecipitation (FNP), and the parameters that influence nanoparticle size were systematically studied. The narrowly distributed and size-controllable NPs formed stable suspensions in aqueous solution without organic solvents. The amphiphilic block polymer PEG-PDLLA played an important role as a drug carrier, and the encapsulation content was as high as 99%. The obtained NPs with high loading of LC exhibited toxicity comparable to those of two commercial formulations at low doses. This confirms that FNP technology is a promising and scalable method for agrochemical delivery.

Chemicals Related in the Paper:

Catalog Number Product Name Structure CAS Number Price
AP68085858 Cyhalothrin solution Cyhalothrin solution 68085-85-8 Price
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