Home
Resources
Publications
Preparation and Characterization of Titanium-Segmented Polyurethane Composites for Bone Tissue Engineering

Preparation and Characterization of Titanium-Segmented Polyurethane Composites for Bone Tissue Engineering

Fernando Javier Aguilar-Perez, Rossana Vargas-Coronado, Jose Manuel Cervantes-Uc, Juan Valerio Cauich-Rodriguez, Raul Rosales-Ibañez, Juan Jose Pavon-Palacio, Yadir Torres-Hernandez, Jose Antonio Rodriguez-Ortiz

J Biomater Appl. 2018 Jul;33(1):11-22.

PMID: 29726734

Abstract:

Segmented polyurethanes were prepared with polycaprolactone diol as soft segment and 4,4-methylene-bis cyclohexyl diisocyanate and l-glutamine as the rigid segment. These polyurethanes were filled with 1 wt.% to 5 wt.% titanium particles (Ti), physicochemically characterized and their biocompatibility assessed using human dental pulp stem cells and mice osteoblasts. Physicochemical characterization showed that composites retained the properties of the semicrystalline polyurethane as they exhibited a glass transition temperature (Tg) between -35°C and -45°C, melting temperature (Tm) at 52°C and crystallinity close to 40% as determined by differential scanning calorimetry. In agreement with this, X-ray diffraction showed reflections at 21.3° and 23.6° for polycaprolactone diol and reflections at 35.1°, 38.4°, and 40.2° for Ti particles suggesting that these particles are not acting as nucleating sites. The addition of up to 5 wt.% of Ti reduced both, tensile strength and maximum strain from 1.9 MPa to 1.2 MPa, and from 670% to 172% for pristine and filled polyurethane, respectively. Although there were differences between composites at low strain rates, no significant differences in mechanical behavior were observed at higher strain rate where a tensile stress of 8.5 MPa and strain of 223% were observed for 5 wt.% composites. The addition to titanium particles had a beneficial effect on both human dental pulp stem cells and osteoblasts viability, as it increased with the amount of titanium in composites up to 10 days of incubation.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP36890683	Polycaprolactone diol		36890-68-3	Price

As a specialist in analytical chemical Products, Alfa Chemistry offers consumers a wealth of raw materials and a full range of technologies and services.

QUICK LINKS

HEADQUARTERS

Tel:

Fax:

Email: