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Preparation and Crystal Structure of a Trihydrate of Paracetamol

Pamela A McGregor, David R Allan, Simon Parsons, Colin R Pulham

J Pharm Sci. 2002 May;91(5):1308-11.

PMID: 11977106

Abstract:

This work reports the preparation and crystal structure of a trihydrate of paracetamol. Crystals were grown by slow cooling of an aqueous solution of paracetamol to 0 degrees C. Single-crystal X-ray diffraction shows that the trihydrate crystallizes in the orthorhombic crystal system, space group Pbca, Z = 8, a = 7.3324(16), b = 12.590(3), c = 22.636(6) A, V = 2089.7(9) A(3). The crystals of the trihydrate dehydrate rapidly at 20 degrees C to give anhydrous paracetamol as its monoclinic form.

Chemicals Related in the Paper:

Catalog Number Product Name Structure CAS Number Price
AS24332 Crystal Violet-d6 trihydrate Crystal Violet-d6 trihydrate Price
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