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Preparation and Quality Control of ¹⁷⁷Lu-[tris(1,10-phenanthroline) lutetium(III)] Complex for Therapy

Preparation and Quality Control of ¹⁷⁷Lu-[tris(1,10-phenanthroline) lutetium(III)] Complex for Therapy

Hassan Yousefnia, Amir R Jalilian, S Zolghadri, A Bahrami-Samani, S Shirvani-Arani, M Ghannadi-Maragheh

Nucl Med Rev Cent East Eur. 2010;13(2):49-54.

PMID: 21598226

Abstract:

The ¹⁷⁷Lu-[tris(1,10-phenanthroline)lutetium(III)] complex (¹⁷⁷Lu-PQ3) was prepared successfully with high radiochemical purity (> 99%). Lu-177 chloride was obtained by thermal neutron flux (4 × 10¹³ n.cm⁻².s⁻¹) of natural Lu₂(NO₃)₃ sample, dissolved in acidic media. The radiochemical yield was checked by measuring the radiochemical purity of the (177)Lu-PQ complex by ITLC (10 mM DTPA, pH = 5, as mobile phase). The final complex solution was injected intravenously into wild-type male rats and bio-distribution of the complex was checked for up to 48 hours. The dose limiting organs were shown to be the reticulu-endothelial system. The bio-distribution of the labelled compounds in tumour-bearing animals is under investigation.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP10099668	Lutetium(III) chloride		10099-66-8	Price

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