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Preparation Method of Penicillin V Potassium β-cyclodextrin Inclusion

Preparation Method of Penicillin V Potassium β-cyclodextrin Inclusion

Xiao Wu, Shouzhong Yang, Shangwen Yang, Xiaofang Yang, Yue Wang, Yangping Liu, Meng Liu, Qian Zhang, LiYing Peng, Lei Chen, Qing Huo

Pak J Pharm Sci. 2018 Jul;31(4(Special)):1633-1638.

PMID: 30203751

Abstract:

In order to conceal the unpleasant smell of pharmaceutical raw materials of Penicillin V potassium, we use β-cyclodextrin (β-CD) as a drug carrier. The Penicillin V potassium β-CD inclusion complex was prepared by saturated aqueous solution method; the characterization of penicillin V potassium β-CD inclusion complex is determined by scanning electron microscopy, Differential Scanning Calorimeter (DSC) and X-ray Diffraction (XRD), the formation constants of the complexes were determined by UV spectrophotometry; based on the results obtained from the orthogonal experimental design, the optimum preparation process are summarized as follow: β-CD: Penicillin V potassium = 4: 1 (molar ratio), stirring temperature 50 centigrade, stirring time 12h, the encapsulation efficiency is 29.40%.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP87081	Penicillin V		87-08-1	Price

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