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Preparation of Fluorescent Magnetic Nanodiamonds and Cellular Imaging

Preparation of Fluorescent Magnetic Nanodiamonds and Cellular Imaging

In Pin Chang, Kuo Chu Hwang, Chi-Shiun Chiang

J Am Chem Soc. 2008 Nov 19;130(46):15476-81.

PMID: 18939829

Abstract:

Magnetic nanodiamonds were prepared via solid-state microwave arcing of a nanodiamond-ferrocene mixed powder in a focused microwave oven. High-resolution transmission electron microscope (HRTEM) images show that a magnetic nanodiamond is composed of iron nanoparticles encapsulated by graphene layers on the surface of nanodiamonds. Fluorescence property was introduced onto magnetic nanodiamonds by chemical modification of magnetic nanodiamonds via surface grafting of poly(acrylic acids) and fluorescein o-methacrylate. Fluorescent magnetic nanodiamonds are water soluble with a solubility of approximately 2.1 g/L. Cellular-imaging experiments show that fluorescent magnetic nanodiamonds could be ingested by HeLa cells readily in the absence of agonist (i.e., folate) moieties on the surface of nanodiamonds.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP480439154	Fluorescein O-methacrylate		480439-15-4	Price
LS775184	Poly(fluorescein O-methacrylate)			Price

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