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Preparation of Poly(ethylene Glycol)-Block-Poly(caprolactone) Copolymers and Their Applications as Thermo-Sensitive Materials

Preparation of Poly(ethylene Glycol)-Block-Poly(caprolactone) Copolymers and Their Applications as Thermo-Sensitive Materials

Moon Suk Kim, Kwang Su Seo, Gilson Khang, Sun Hang Cho, Hai Bang Lee

J Biomed Mater Res A. 2004 Jul 1;70(1):154-8.

PMID: 15174120

Abstract:

The polymerization of epsilon-caprolactone (epsilon-CL) was initiated by the terminal alcohol of methoxy poly(ethylene glycol) (MPEG) as an initiator via activated ring-opening polymerization in the presence of HCl. Et2O as a monomer activator. The molecular weights of the poly(epsilon-caprolactone) (PCL) in MPEG-PCL diblock copolymers controlled with the feed ratio of epsilon-CL to MPEG. The polymerization was preceded by living fashion with no termination or chain transfer. This polymerization procedure offered MPEG-PCL diblock copolymers with well-defined structures. The gel-to-sol transitions of MPEG-PCL diblock copolymer solutions were also examined. The diblock copolymers synthesized with various MPEG and PCL lengths were dissolved in water at 80 degrees C in various concentrations. The polymer solutions formed gel at room temperature. The formed gel became fluids again by increasing the temperature. The gel-to-sol transition showed strong dependence on the length of the MPEG and PCL diblock segments. When the polymer solution was injected into rat, it became a gel at body temperature. The formed gel maintained for 1 month. We confirmed that MPEG-PCL diblock copolymers with well-defined structures served as new thermo-sensitive biomaterials.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
LS74322	Methoxy poly(ethylene glycol)-block-poly(ε-caprolactone)			Price

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