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Preparation of Polyelectrolyte Complex Nanoparticles of Chitosan and poly(2-acry1amido-2-methylpropanesulfonic Acid) for Doxorubicin Release

Preparation of Polyelectrolyte Complex Nanoparticles of Chitosan and poly(2-acry1amido-2-methylpropanesulfonic Acid) for Doxorubicin Release

Liping Zhang, Jie Wang, Caihua Ni, Yanan Zhang, Gang Shi

Mater Sci Eng C Mater Biol Appl. 2016 Jan 1;58:724-9.

PMID: 26478364

Abstract:

A new kind of polyelectrolyte complex (PEC) based on cationic chitosan (CS) and anionic poly(2-acry1amido-2-methylpropanesulfonic acid) (PAMPS) was prepared using a polymer-monomer pair reaction system. Chitosan was mixed with 2-acry1amido-2-methylpropanesulfonic acid) (AMPS) in an aqueous solution, followed by polymerization of AMPS. The complex was formed by electrostatic interaction of NH3(+) groups of CS and SO3(-) groups of AMPS, leading to a formation of complex nanoparticles of CS-PAMPS. A series of nanoparticles were obtained by changing the weight ratio of CS to AMPS, the structure and properties of nanoparticles were investigated. It was observed that the nanoparticles possessed spherical morphologies with average diameters from 255 nm to 390 nm varied with compositions of the nanoparticles. The nanoparticles were used as drug vehicles for doxorubicin, displaying relative high drug loading rate and encapsulation rate. The vitro release profiles revealed that the drug release could be controlled by adjusting pH of the release media. The nanoparticles demonstrated apparent advantages such as simple preparation process, free of organic solvents, size controllable, good biodegradability and biocompatibility, and they could be potentially used in drug controlled release field.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP27119079	Poly(2-acrylamido-2-methyl-1-propanesulfonic acid) solution		27119-07-9	Price

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