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Preparative Manipulation of Gold Nanoparticles by Reversible Binding to a Polymeric Solid Support

Preparative Manipulation of Gold Nanoparticles by Reversible Binding to a Polymeric Solid Support

Ovadia Abed, Alexander Vaskevich, Rina Arad-Yellin, Abraham Shanzer, Israel Rubinstein

Chemistry. 2005 Apr 22;11(9):2836-41.

PMID: 15744704

Abstract:

A preparative scheme is presented for controlled modification of gold nanoparticles (NPs) by using reversible binding to a polymeric solid support through boronic acid chemistry. Octanethiol-capped Au NPs were bound to a boronic acid functionalized resin by custom-synthesized bifunctional linker molecules. The NPs were chemically released from the resin to the solution, with one (or a few) linker molecules embedded in their capping layer. This was confirmed by rebinding the linker-derivatized NPs to a boronic resin, exploiting the reversibility of the boronic acid/diol chemistry. The same scheme was employed to demonstrate a new method for affinity separation of NPs by means of a solid-phase reaction. The use of boronic acid provides versatility and chemical reversibility, while the polymeric solid support affords the separation and preparative aspects. The method presented here may be useful in various facets of NP handling, manipulation, and separation.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
LS73269	Octanethiol functionalized gold nanoparticles			Price

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