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Presynaptic Inhibition of Nociceptive Neurotransmission by Somatosensory Neuron-Secreted Suppressors

Kaicheng Li, Bing Cai, Changlin Li, Xu Zhang

Sci China Life Sci. 2017 Sep;60(9):1013-1018.

PMID: 28624955

Abstract:

Noxious stimuli cause pain by activating cutaneous nociceptors. The Aδ- and C-fibers of dorsal root ganglion (DRG) neurons convey the nociceptive signals to the laminae I-II of spinal cord. In the dorsal horn of spinal cord, the excitatory afferent synaptic transmission is regulated by the inhibitory neurotransmitter γ-aminobutyric acid and modulators such as opioid peptides released from the spinal interneurons, and by serotonin, norepinepherine and dopamine from the descending inhibitory system. In contrast to the accumulated evidence for these central inhibitors and their neural circuits in the dorsal spinal cord, the knowledge about the endogenous suppressive mechanisms in nociceptive DRG neurons remains very limited. In this review, we summarize our recent findings of the presynaptic suppressive mechanisms in nociceptive neurons, the BNP/NPR-A/PKG/BKCa channel pathway, the FSTL1/α1Na+-K+ ATPase pathway and the activin C/ERK pathway. These endogenous suppressive systems in the mechanoheat nociceptors may also contribute differentially to the mechanisms of nerve injury-induced neuropathic pain or inflammation-induced pain.

Chemicals Related in the Paper:

Catalog Number Product Name Structure CAS Number Price
AP331656929 ERK Inhibitor III - CAS 331656-92-9 ERK Inhibitor III - CAS 331656-92-9 331656-92-9 Price
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