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Presynaptic Involvement of Nitric Oxide in Dopamine D1/D5 Receptor-Induced Sustained Enhancement of Synaptic Currents Mediated by Ionotropic Glutamate Receptors in the Rat Hippocampus

Presynaptic Involvement of Nitric Oxide in Dopamine D1/D5 Receptor-Induced Sustained Enhancement of Synaptic Currents Mediated by Ionotropic Glutamate Receptors in the Rat Hippocampus

S N Yang

Neurosci Lett. 1999 Jul 30;270(2):87-90.

PMID: 10462104

Abstract:

Using whole-cell patch-clamp recordings, the study tested the possibility whether nitric oxide (NO) was involved in dopamine D1/D5 receptor (D1/D5r)-induced sustained enhancement of excitatory postsynaptic currents (EPSCs) mediated by ionotropic glutamate receptors in rat hippocampal slices. Activation of D1/D5r by a selective agonist, 50 microM (+/-)-6-chloro-PB hydrobromide, elicited not only a sustained enhancement but also an increased frequency of spontaneous EPSC. The D1/D5r-induced effect was associated with decreases in paired-pulse facilitation (PPF). A selective inhibitor of neuronal NO synthase (nNOS), 100 microM 7-nitroindazole monosodium salt, substantially attenuated both the magnitudes of D1/D5r-induced enhancement and PPF decrease. These results suggest that presynaptic effects mediated by NO, possibly synthesized by nNOS, are involved in D1/D5-induced sustained enhancement of synaptic currents mediated by ionotropic glutamate receptors in the hippocampus.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP71636618	(±)-6-Chloro-PB hydrobromide		71636-61-8	Price

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