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Preventive Effects of Cedrol Against Alopecia in Cyclophosphamide-Treated Mice

Preventive Effects of Cedrol Against Alopecia in Cyclophosphamide-Treated Mice

Shan-Shan Chen, Yan Zhang, Qiu-Li Lu, Zhe Lin, Yuqing Zhao

Environ Toxicol Pharmacol. 2016 Sep;46:270-276.

PMID: 27522546

Abstract:

Although numerous hypotheses have been proposed to prevent chemotherapy-induced alopecia (CIA), effective pharmaceuticals have yet to be developed. In our study, the back hairs of C57BL/6 mice were factitiously removed. These mice were then treated with cedrol or minoxidil daily. Mice with early-stage anagen VI hair follicles were treated with cyclophosphamide (CYP, 125mg/kg) to induce alopecia. The CYP-damaged hair follicles were observed and quantified by using a digital photomicrograph. The results demonstrated that the minoxidil-treated mice suffered from complete alopecia similar to the model 6days after CYP administration. Simultaneously, the cedrol-treated (200mg/kg) mice manifested mild alopecia with 40% suppression. Histological observation revealed that anagen hair follicles of the cedrol-pretreated mice (82.5%) likely provided from damage compared with the sparse and dystrophic hair follicles of the model mice (37.0%). Therefore, the use of topical cedrol can prevent hair follicle dystrophy and provide local protection against CIA.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP77532	(+)-Cedrol		77-53-2	Price

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