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[Primary Neuroendocrine Tumors of the Breast: A Retrospective Study of 21 Cases and Literature Review]

[Primary Neuroendocrine Tumors of the Breast: A Retrospective Study of 21 Cases and Literature Review]

J Feki, N Fourati, H Mnif, A Khabir, N Toumi, A Khanfir, T Boudawara, H Amouri, J Daoud, M Frikha

Cancer Radiother. 2015 Aug;19(5):308-12.

PMID: 26215367

Abstract:

Purpose:
The aim of the present study was to discuss the epidemiology, clinical and pathologic features, treatment, and prognosis of primary neuroendocrine carcinomas of the breast.
Patients and methods:
We report 21 cases diagnosed over a period of 12 years (1995-2011) at the university hospital of Sfax. A review of the clinical data with pathology and immunohistochemistry study was carried out for all the cases.
Results:
The average age was 62 years (34-86 years). At the time of the diagnosis, tumours were classified T1 and T2 (16 cases), N1 (11 cases) and M1 in two cases. The histological examination has shown 13 cases of solid neuroendocrine carcinoma, six cases of large cell type and two cases of atypical carcinoid. Grade I and II SBR were found in 18 cases. Eighty-one percent of the tumours were reactive for synaptophysin; all tumours were positive for chromogranin. Thirteen (61.9%) tumours were estrogen receptor-positive and 12 (57.5%) progesterone receptor-positive. Nineteen (90.5%) tumours were negative for HER2/neu. Overall five-year survival was 72.7%. All patients had surgical treatment with modified radical mastectomy in 13 cases. Adjuvant treatment was indicated according to histopronostic elements.
Conclusion:
For primary neuroendocrine carcinoma of the breast, multivariate analysis identified three predictive factors for mortality: disease stage, histological grade and lymph node involvement.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP928207027	ErbB2 Inhibitor II - CAS 928207-02-7		928207-02-7	Price

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