0

Primary Structure of Bovine Brain Acidic Fibroblast Growth Factor (FGF)

F Esch, N Ueno, A Baird, F Hill, L Denoroy, N Ling, D Gospodarowicz, R Guillemin

Biochem Biophys Res Commun. 1985 Dec 17;133(2):554-62.

PMID: 4084288

Abstract:

The major anionic mitogenic polypeptide for endothelial cells, acidic fibroblast growth factor (FGF), has been purified to homogeneity from bovine brain and its complete primary structure established by gas-phase sequence analysis. The 140 amino acid (Mr 16,000) protein has been previously shown to be a potent growth factor for many diverse cell types of mesodermal origin, in vitro, and an angiogenic agent, in vivo. The amino acid sequence of bovine brain acidic FGF has a 53% absolute homology with that of bovine pituitary basic FGF suggesting that these endothelial cell mitogens are derived from a single ancestral gene.

Chemicals Related in the Paper:

Catalog Number Product Name Structure CAS Number Price
AP106096939-A Fibroblast Growth Factor-Basic from bovine pituitary Fibroblast Growth Factor-Basic from bovine pituitary 106096-93-9 Price
qrcode