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Pro-apoptotic and Anti-Angiogenic Properties of the α /β-thujone Fraction From Thuja Occidentalis on Glioblastoma Cells

Pro-apoptotic and Anti-Angiogenic Properties of the α /β-thujone Fraction From Thuja Occidentalis on Glioblastoma Cells

Angelo Torres, Yosselyn Vargas, Daniel Uribe, Cristian Carrasco, Cristian Torres, René Rocha, Carlos Oyarzún, Rody San Martín, Claudia Quezada

J Neurooncol. 2016 May;128(1):9-19.

PMID: 26900077

Abstract:

The most aggressive type of brain tumor is glioblastoma multiforme, which to date remains incurable. Thuja occidentalis is used in homeopathy for the treatment of cancer, however, its mechanism of action remains unknown. We set out to study the effects of thujone fractions of Thuja on glioblastoma using in vitro and in vivo models. We found that the α/ β-thujone fraction decrease the cell viability and exhibit a potent anti-proliferative, pro-apoptotic and anti-angiogenic effects in vitro. In vivo assays showed that α /β-thujone promotes the regression of neoplasia and inhibits the angiogenic markers VEGF, Ang-4 and CD31 into the tumor.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP76231760-B	α,β-Thujone		76231-76-0	Price

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