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Probing Key Targets in Insulin Signaling and Adipogenesis Using a Methanolic Extract of Costus Pictus and Its Bioactive Molecule, Methyl Tetracosanoate

Kusampudi Shilpa, Kadapakkam Nandabalan Sangeetha, Velusamy Shanmuganathan Muthusamy, Sundaresan Sujatha, Baddireddi Subadhra Lakshmi

Biotechnol Lett. 2009 Dec;31(12):1837-41.

PMID: 19693444

Abstract:

A methanolic extract of Costus pictus (CPME) showed optimum anti-diabetic activity at 100 ng/ml. Bioactivity-guided purification of CPME led to the isolation of methyl tetracosanoate (MT) which showed an optimum glucose uptake at 1 ng/ml. CPME at 10 mug/ml inhibited adipogenesis whereas fully differentiated adipocytes exhibited a 3-fold increase in lipid accumulation compared to pre-adipocytes. Gene and protein expression of key targets in insulin signaling and adipogenesis pathway revealed that CPME exhibited anti-diabetic activity along with anti-adipogenic activity whereas MT demonstrated only anti-diabetic activity.

Chemicals Related in the Paper:

Catalog Number Product Name Structure CAS Number Price
AP2442491 Methyl tetracosanoate Methyl tetracosanoate 2442-49-1 Price
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