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Production of Antifungal p-Aminobenzoic Acid in Lysobacter Antibioticus OH13

Production of Antifungal p-Aminobenzoic Acid in Lysobacter Antibioticus OH13

Pedro Laborda, Yangyang Zhao, Jun Ling, Rongxian Hou, Fengquan Liu

J Agric Food Chem. 2018 Jan 24;66(3):630-636.

PMID: 29283262

Abstract:

Among Lysobacter species, Lysobacter antibioticus has been demonstrated to be an interesting source of antimicrobial metabolites for the biocontrol of plant diseases. Although the antibacterial activity was attributed to N-oxide phenazines, the active compounds involved in the antifungal function remained unknown. In this work, an antifungal compound was isolated and identified as p-aminobenzoic acid (pABA). Antifungal activity screening revealed that pABA shows activity against a number of plant pathogens. The genes involved in the synthetic route of this compound in OH13 were identified. Further, the production of pABA was optimized by modification of the carbon source using engineered L. antibioticus OH13 strains.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP150130-B	Aminobenzoic acid		150-13-0	Price

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