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Production of (R)-3-hydroxybutyric Acid by Fermentation and Bioconversion Processes With Azohydromonas Lata

Production of (R)-3-hydroxybutyric Acid by Fermentation and Bioconversion Processes With Azohydromonas Lata

Charles U Ugwu, Yutaka Tokiwa, Toshio Ichiba

Bioresour Technol. 2011 Jun;102(12):6766-8.

PMID: 21507620

Abstract:

Feasibility of producing (R)-3-hydroxybutyric acid ((R)-3-HB) using wild type Azohydromonas lata and its mutants (derived by UV mutation) was investigated. A. lata mutant (M5) produced 780 m g/l in the culture broth when sucrose was used as the carbon source. M5 was further studied in terms of its specificity with various bioconversion substrates for production of (R)-3-HB. (R)-3-HB concentration produced in the culture broth by M5 mutant was 2.7-fold higher than that of the wild type strain when sucrose (3% w/v) and (R,S)-1,3-butanediol (3% v/v) were used as carbon source and bioconversion substrate, respectively. Bioconversion of resting cells (M5) with glucose (1% v/w), ethylacetoacetate (2% v/v), and (R,S)-1,3-butanediol (3% v/v), resulted in (R)-3-HB concentrations of 6.5 g/l, 7.3g/l and 8.7 g/l, respectively.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP625729	(R)-3-Hydroxybutyric acid		625-72-9	Price

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