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Promotion by SR 48692 of Gastric Emptying and Defaecation in Rats Suggesting a Role of Endogenous Neurotensin

T Croci, A Giudice, L Manara, D Gully, G Le Fur

Br J Pharmacol. 1995 Jun;115(3):383-4.

PMID: 7582445

Abstract:

We investigated the influence of the nonpeptide neurotensin receptor antagonist, SR 48692, administered orally, on gastric emptying and on acute defaecation. SR 48692 dose-dependently (ED50 approximately 0.7 microgram kg-1) increased gastric emptying of a food suspension, but it had no effect on that of a non-caloric meal. SR 48692 also dose-dependently promoted defaecation and increased faecal water content. We suggest that antagonism of endogenous neurotensin accounts for the gastric emptying and defaecation promoting action of SR 48692.

Chemicals Related in the Paper:

Catalog Number Product Name Structure CAS Number Price
AP146362701 SR 48692 SR 48692 146362-70-1 Price
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