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Promotion of Insulin-like Growth Factor II in Cell Proliferation and Epithelial-Mesenchymal Transition in Hepatocellular Carcinoma

Promotion of Insulin-like Growth Factor II in Cell Proliferation and Epithelial-Mesenchymal Transition in Hepatocellular Carcinoma

Yan Ma, Yanfang Chen, Lei Chen, Zhi Liu, Mio-Leng Ieong, Fei Gao, Wei Huang

J Cancer Res Ther. 2018;14(4):844-850.

PMID: 29970663

Abstract:

Aim:
This study aims to investigate the involvement of insulin-like growth factor II (IGF-II) in human hepatocellular carcinoma (HCC) proliferation and metastasis.
Materials and methods:
The effects of IGF-II on cell proliferation, cell cycle, apoptosis, cell migration, and invasion in HCC Huh7 cells were investigated in the study.
Results:
IGF-II promoted cell proliferation and colony formation, suppressed cell apoptosis in Huh7 cells by promoting cell cycle progression, induced epithelial-mesenchymal transition (EMT) phenotypes, and enhanced the metastatic potential of HCC in vitro.
Conclusion:
Our results revealed that IGF-II promotes cell proliferation and EMT in HCC cells.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
IAR4248605	Insulin-like Growth Factor-II human			Price

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