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Propafenone-associated Gross Hematuria: A Case Report and Review of the Literature

Propafenone-associated Gross Hematuria: A Case Report and Review of the Literature

Shuqing Chen, Wenhui Ding, Jing Ye, Zining Wang, Xia Zhao, Yimin Cui

Clin Ther. 2019 Aug;41(8):1614-1620.

PMID: 31164244

Abstract:

Purpose:
Propafenone hydrochloride has been widely used for the treatment of supraventricular and ventricular arrhythmias. We present a case report of an 81-year-old patient with propafenone-associated gross hematuria.
Methods:
The Naranjo Adverse Drug Reaction Probability Scale was used to assess causality. We also performed a literature search to find publications that report propafenone-associated gross hematuria.
Findings:
The Naranjo scale generated a score of 6, suggesting a probable association between gross hematuria and propafenone therapy. Thirteen publications that reported an association between gross hematuria and propafenone administration were found.
Implications:
A probable association exists between gross hematuria and propafenone.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP34183227-A	Propafenone hydrochloride		34183-22-7	Price

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