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Propionibacterium Acnes Related Anti-Inflammation and Skin Hydration Activities of Madecassoside, a Pentacyclic Triterpene Saponin From Centella Asiatica

Propionibacterium Acnes Related Anti-Inflammation and Skin Hydration Activities of Madecassoside, a Pentacyclic Triterpene Saponin From Centella Asiatica

Xueqing Shen, Miaomiao Guo, Haiyuan Yu, Dan Liu, Zhi Lu, Yanhua Lu

Biosci Biotechnol Biochem. 2019 Mar;83(3):561-568.

PMID: 30452312

Abstract:

Madecassoside is a major pentacyclic triterpene saponin from Centella asiatica with multiple pharmaceutical activities. In this study, we focused on its Propionibacterium acnes related anti-inflammation and skin hydration activities, both of which play important roles in skin homeostasis and barrier function. Madecassoside significantly inhibited the pro-inflammatory cytokine IL-1β, TLR2 and nuclear translocation of NF-κB in P. acnes stimulated THP-1 human monocytic cells. In addition, madecasssoside exhibited significant effects on enhancement of skin hydration through increasing the key moisturizing contributors of aquaporin-3, loricrin and involucrin in HaCaT keratinocytes as well as hyaluronan (HA) secretion in human dermal fibroblasts. The upregulation of HA synthases (HAS1, HAS2, HAS3) and inhibition to ROS formation accounted for the increment of HA content. Together, the in vitro study implied the potential medical and cosmetic application of madecassoside in skin protection.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP34540222	Madecassoside		34540-22-2	Price

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