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Propolis Allergy. (II). The Sensitizing Properties of 1,1-dimethylallyl Caffeic Acid Ester

Propolis Allergy. (II). The Sensitizing Properties of 1,1-dimethylallyl Caffeic Acid Ester

B M Hausen, E Wollenweber, H Senff, B Post

Contact Dermatitis. 1987 Sep;17(3):171-7.

PMID: 3677659

Abstract:

As shown in the preceding paper, propolis or bee-glue is the cause of an increasing number of allergic reactions in persons using it in external preparations and cosmetics. Propolis and its main contact allergen, 1,1-dimethylallyl caffeic acid ester, designated LB-1, show strong sensitizing properties in patients as well as in guinea pig experiments. 9 patients have been patch tested with this compound, 8 of whom reacted strongly. Chemical separation of different propolis samples and poplar bud extracts reveal that LB-1 is always present. Poplar bud secretion is the bee's major source for propolis and hence the origin of LB-1. A warning is indicated, in agreement with several other authors, that propolis should not be used in topical products because of its strong sensitizing properties.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP118971612	Caffeic acid 1,1-dimethylallyl ester		118971-61-2	Price

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