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Propolis Allergy. (III). Sensitization Studies With Minor Constituents

Propolis Allergy. (III). Sensitization Studies With Minor Constituents

B M Hausen, E Wollenweber

Contact Dermatitis. 1988 Oct;19(4):296-303.

PMID: 3219839

Abstract:

87% of the propolis product "LB-1", originally reported to be 1,1-dimethyl-allyl caffeic acid ester, was shown by GC/MS analysis to consist of 3 isomeric pentenyl caffeates, 63% of which are 1,1-dimethylallyl caffeate. These pentenyl caffeates proved to be the major sensitizers of propolis and of poplar bud secretion in our previous study. In addition, 3 further minor allergens have now been investigated. Experimental sensitization indicates that phenylethyl caffeate is as strong a sensitizer as the major allergen "LB-1", while benzyl salicylate is a moderate sensitizer. Benzyl cinnamate plays only a subordinate role. At least 3 further esters of caffeic acid or cinnamic acid remain to be studied. Interestingly, relationships between propolis and balsam of Peru were found. 8 compounds are common to both materials. Thus "cross-reactions" or concomitant reactions in propolis-sensitive individuals to balsam of Peru are explainable.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP118971612	Caffeic acid 1,1-dimethylallyl ester		118971-61-2	Price

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