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Protamine Sulfate for the Reversal of Enoxaparin Associated Hemorrhage Beyond 12 H

Protamine Sulfate for the Reversal of Enoxaparin Associated Hemorrhage Beyond 12 H

Brian R Lauer, Richard A Nelson, John H Adamski, Joseph Gibbons, Matthew R Janko, Gayathri Ravi, Robert A Barcelona

Am J Emerg Med. 2019 Jan;37(1):174.e5-174.e6.

PMID: 30274763

Abstract:

Clinical practice guidelines recommend protamine sulfate for reversal of enoxaparin associated bleeds dependent on the time from last administration and dose of enoxaparin. We present a case of a hemodynamically unstable patient with an enoxaparin induced abdominal wall hematoma/hemorrhage and the previous enoxaparin administration 21.5 h prior to presentation with a therapeutic anti-Xa assay (0.8 IU/mL) upon assessment in the emergency department. Along with resuscitative efforts, an interdisciplinary team collaborated to administer protamine sulfate 50 mg intravenous once (0.5 mg per 1 mg of enoxaparin) to reverse the therapeutic anticoagulation. Our case demonstrates the importance of monitoring renal function and the potential for accumulation of enoxaparin in patients with renal dysfunction leading to prolonged therapeutic anti-Xa assays. With the availability of anti-Xa assays, future reversal recommendations of enoxaparin associated bleeds using protamine sulfate should include the initial anti-Xa assay as a guide for the dosing regimen.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP9009658	Protamine sulfate		9009-65-8	Price

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