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Proteasome Inhibition by the Natural Products Epoxomicin and Dihydroeponemycin: Insights Into Specificity and Potency

K B Kim, J Myung, N Sin, C M Crews

Bioorg Med Chem Lett. 1999 Dec 6;9(23):3335-40.

PMID: 10612595

Abstract:

While two structurally related epoxyketone-containing antitumor natural products, epoxomicin and eponemycin, share the proteasome as a common intracellular target, they differ in their antiproliferative activity, proteasome subunit binding specificity, and rates of proteasome inhibition. As a first step towards understanding such differences and developing novel proteasome subunit-specific inhibitors, we report here the synthesis and characterization of epoxomicin/dihydroeponemycin chimerae.

Chemicals Related in the Paper:

Catalog Number Product Name Structure CAS Number Price
AP126463647 Dihydroeponemycin Dihydroeponemycin 126463-64-7 Price
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