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Protection Against Tetrodotoxin and Saxitoxin Intoxication by a Cross-Protective Rabbit Anti-Tetrodotoxin Antiserum

Protection Against Tetrodotoxin and Saxitoxin Intoxication by a Cross-Protective Rabbit Anti-Tetrodotoxin Antiserum

B Kaufman, D C Wright, W R Ballou, D Monheit

Toxicon. 1991;29(6):581-7.

PMID: 1926161

Abstract:

A tetrodotoxin-formaldehyde-keyhole limpet hemocyanin conjugate was used to immunize a rabbit for the production of anti-toxin antiserum. The antiserum cross-reacted against both tetrodotoxin (TTX) and saxitoxin (STX), and in a quantitative in vitro assay was able to protect cells in a dose-dependent manner from the effects of either TTX or STX. The antiserum was also able to passively protect mice challenged in vivo with either toxin. Hybridomas producing monoclonal antibodies against toxin were obtained from the spleens of mice immunized with the same conjugate.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
IAR42416735	Anti-phospho-B-Myb (pSer577/581) antibody produced in rabbit			Price

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