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Protection From Reperfusion-Induced Arrhythmias by Polyethylene Glycol 600

Protection From Reperfusion-Induced Arrhythmias by Polyethylene Glycol 600

P Hoffmann, M Klapperstück, J Scholz, M Weise, K P Döpfer

J Pharm Pharmacol. 1993 Dec;45(12):1093-5.

PMID: 7908982

Abstract:

The effects of polyethylene glycol (PEG) 600 on cardiovascular parameters and reperfusion-induced arrhythmias were investigated using a 5-min period of ligation of the left anterior descending coronary artery followed by reperfusion in an anaesthetized open-chest rat model. PEG 600 was effective in reducing reperfusion arrhythmias, such as ventricular fibrillation and ventricular tachycardia. Mortality was decreased from 29.4% (5/17) in the saline-control to 0% (0/14) in the PEG-treated group (P < 0.05). Biochemical investigations during the ischaemia/reperfusion period revealed that PEG infusion resulted in a reduction of cardiac lactate as well as a striking maintenance of the glutathione content of the heart.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP25322683-I	Polyethylene glycol 600		25322-68-3	Price

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