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Protective Effect of Ginsenoside Rh3 Against Anticancer Drug-Induced Apoptosis in LLC-PK1 Kidney Cells

Protective Effect of Ginsenoside Rh3 Against Anticancer Drug-Induced Apoptosis in LLC-PK1 Kidney Cells

Hye Lim Lee, Ki Sung Kang

J Ginseng Res. 2017 Apr;41(2):227-231.

PMID: 28413329

Abstract:

Background:
Ginsenosides are active components of Panax ginseng that exert various health benefits including kidney protection effect. The medicinal activity of ginsenosides can be enhanced by modulating their stereospecificity by heat processing. Ginsenosides Rk2 and Rh3 represent positional isomers of the double bond at C-20(21) or C-20(22).
Methods:
The present study investigated the kidney-protective effects of ginsenosides Rk2 and Rh3 against cisplatin, a platinum based anticancer drug, induced apoptotic damage in renal proximal LLC-PK1 cells.
Results:
As a result, ginsenoside Rh3 shows a stronger protective effect than that shown by Rk2. Cisplatin-induced elevated protein levels of phosphorylated c-Jun N-terminal kinase (JNK), extracellular signal-regulated kinase (ERK), p38, and cleaved caspase-3 decreased after cotreatment with ginsenoside Rh3. The increase in the percentage of apoptotic LLC-PK1 cells induced by cisplatin treatment also significantly reduced after cotreatment with ginsenoside Rh3.
Conclusion:
These results demonstrate that inhibition of the JNK and ERK mitogen-activated protein kinase signaling cascade plays a critical role in mediating the renoprotective effect of ginsenoside Rh3.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP105558267	Ginsenoside Rh3		105558-26-7	Price

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